As of 01/11/09, apparently, McAfee got new definitions that blocked a2uploader from working on my PC. As of 01/14/09, McAfee got newer dfeinitions that caused a2uploader to be deleted from my PC.
Unfortunately, I am using a coprorate laptop and the DAT files are pushed to my PC by corporate eSecurity group. Even if I modify McAfee to allow a2uploader to keep working, within 5 minutes, Corp blows away my changes and a2uploader is gone again.
I will have to get my old (very old) laptop up and running again if I want to continue using a2uploader or maybe move over to my media center PC, which I don't really want to do.
The point here is that it may be your antivirus/spyware app that is causing a2uploader to not detect your phone. You may want to go into what ever app you're using and add a2uploader to the exceptions list(s) so that it does not get blocked, quarantined, etc.. Of course, if you chose to do this, you do so at your own risk, and I will not be held responsible if you have a perverted copy of a2uploader that has an actual virus/spyware/malware in it.
I guess I can no longer help, until I can figure out a solution on my side for me to continue using a2uploader... Well, it was fun while it lasted.